The juvenile hormone signaling pathway in insect development. | Semantic Scholar (2024)

A systematic RNA interference screening to identify RTKs involved in regulating JH biosynthesis in the CA of adult Blattella germanica females found that the epidermal growth factor receptor (Egfr) is required for promoting JH biochemistry in theCA of adult females.

The results suggest that the membrane-initiated signaling pathway modifies the DNA-binding activity of MET via phosphorylation and thus facilitates the genomic responses to JH, revealing an interplay of genomic and nongenomic signaling mechanisms of JH.

The virus, Musca domestica salivary gland hytrosavirus (MdSGHV), induced the upregulation of various components of the siRNA, innate antimicrobial immune, and autophagy pathways, which potentially explains the significant reduction of hemolymph sesquiterpenoids levels, the refusal to mate, and the complete shutdown of egg development in viremic females.

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It is found that methoprene, administered by feeding or by topical application, disrupts the metamorphic reorganization of the central nervous system, salivary glands, and musculature in a dose-dependent manner.

It is shown that a transcriptional coactivator of the ecdysteroid receptor complex, FISC, acts as a functional partner of Met in mediating JH-induced gene expression and directly activate transcription of JH target genes.

It is shown by overexpression studies that gce can substitute in vivo for Met, alleviating preadult but not adult phenotypic characters and that RNA interference-driven knockdown of gce expression in transgenic flies results in preadult lethality in the absence of MET.

This work cloned the Met+ gene by transposable P-element tagging and found reduced transcript level in several mutant alleles, showing that underproduction of the normal gene product can lead to insecticide resistance.

Recent advances are highlighted which demonstrate the importance of transcription factors from the bHLH-PAS and nuclear receptor families in mediating the response to JH.

It is concluded that the neurotransmitter glutamate promotes dpp expression in the CA, which stimulates JH biosynthesis through Tkv and Mad by upregulating jhamt transcription at the early larval stages to prevent premature metamorphosis.

It is concluded that Wnt signaling cross-talks with JH signaling by suppressing transcription of Met and gce, genes that encode for putative JH receptors, which induces down-regulation of Kr-h1expression and eventually derepresses br expression in the Drosophila early larval stages.

Results suggest that Met may function as a JH‐dependent transcription factor and ligand‐dependent gene regulation in Drosophila melanogaster.

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